Tuesday, March 15, 2011

Chordoma Treatment

 Chondroid chordomas appear to have a more indolent clinical course.
In most cases, complete surgical resection followed by radiation therapy offers the best chance of long-term control. Incomplete resection of the primary tumor makes controlling the disease more difficult and increases the odds of recurrence.
Chordomas are relatively radioresistant, requiring high doses of radiation to be controlled. The proximity of chordomas to vital neurological structures such as the brain stem and nerves limits the dose of radiation that can safely be delivered. Therefore, highly focused radiation such as proton therapy and carbon ion therapy are more effective than conventional x-ray radiation.
There are no drugs currently approved to treat chordoma, however a clinical trial conducted in Italy using the PDGFR inhibitor Imatinib demonstrated a modest response in some chordoma patients. The same group in Italy found that the combination of imatinib and sirolimus caused a response in several patients whose tumors progressed on imatinib alone.



Dr.Sanjay Mongia
Web : http://www.gammaknifeonline.in/
Email: gamma@gammaknifeonline.in

Chordoma Treatment in India

There are three histological variants of chordoma: classical (or "conventional") , chondroid and dedifferentiated.
  • The histological appearance of classical chordoma is of a lobulated tumor composed of groups of cells separated by fibrous septa. The cells have small round nuclei and abundant vacuolated cytoplasm, sometimes described as physaliferous (having bubbles or vacuoles).
  • Chondroid chordomas histologically show features of both chordoma and chondrosarcoma

Dr.Sanjay Mongia
web :http://www.gammaknifeonline.in/
Email : gamma@gammaknifeonline.in

Monday, March 14, 2011

Chordoma Treatment in Mumbai

Chordoma treatment

Chordoma is a rare slow-growing malignant neoplasm thought to arise from cellular remnants of the notochord. The evidence for this is the location of the tumors (along the neuraxis), the similar immunohistochemical staining patterns, and the demonstration that notochordal cells are preferentially left behind in the clivus and sacrococcygeal regions when the remainder of the notochord regresses during fetal life.
Dr.Sanjay Mongia
gamma@gammaknifeonline.in
http://www.gammaknifeonline.in/